6Colonia del Sacramento, Uruguay

Founded by the Portuguese in 1680, Colonia del Sacramento is one of the oldest towns in Uruguay. Located on the banks of the Río de la Plata, the town is a mix of Portuguese and Spanish colonial architecture, reflecting the town’s turbulent history of colonial rivalry.

Colonia del Sacramento is recognized by UNESCO for its well-preserved historic quarter, where visitors can wander through narrow, cobbled streets lined with colorful colonial houses. The town’s Plaza Mayor, ancient ruins, and charming waterfront make it a fascinating stop in South America.