10 Loneliest Road Trips in the USA

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6Route 66 – California’s Mojave Desert Section

While most of Route 66 is a popular tourist destination, the Mojave Desert section in California from Barstow to Needles remains one of the road’s loneliest stretches.

This area of dry, barren landscape and scattered ghost towns has a haunting quality, with remnants of old motels and gas stations. The open highway and empty surroundings provide an experience that feels like a step back in time, surrounded by vast, silent desert.